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  3. New treatment for ALS: FDA approved New ALS Medication 2022

New treatment for ALS: FDA approved New ALS Medication 2022

Discover groundbreaking treatments for ALS. Explore innovative therapies offering hope for improved quality of life. Learn more now!

  • Neurosurgery Treatment
By Ipshita Ghoshal 26th Oct '22 27th Mar '24
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Overview

Amyotrophic Lateral Sclerosis (ALS), also called Lou Gehrig’s disease. According to Global estimates, ALS's annual incidence and prevalence are 4 to 6 per 100,000 and 3 to 5 per 100,000, respectively. The usual age of onset of ALS is 55 to 65 years old. Out of all the ALS cases, 10% of them are people who have inherited the disease from their parents. The ratio of males to females is 2:1.
 

The Foundation for Research on Rare Diseases and Disorders (FRRDD) estimates that there are 5 cases of ALS per 100,000 people in India.

ALS is a severe disorder; hence, there is an absolute need to find a new treatment for ALS that can prolong the lives of people suffering from the disease.

The National Institute of Neurological Disorders and Stroke (NINDS) and other organizations are working diligently to further our understanding of this devastating disease and to find effective therapies.

Let’s look at the latest developments in the medical field regarding ALS!!

On 29th September 2022, the FDA approved a new ALS medicine. Relyvrio is the new ALS medication approved. It is a combination of two medicines, namely sodium phenylbutyrate and taurursodiol. The drug has increased the overall survival rate among people during clinical trials. 
 

Are you curious to know how Relyvrio will cure ALS?? Continue reading to find out!!

How did the Relyvrio study work?

People with ALS gradually lose their ability to walk, move, swallow or breathe. About 80 percent of people with ALS pass away within two to five years of the onset of the disease. The new treatment is not yet the ALS potential cure. The powdered mixture is combined with water and consumed or taken through a feeding tube. It intends to halt the progression of the illness by defending brain and spinal cord nerve cells damaged by ALS.
 

Relyvrio, produced by Amylyx Pharmaceuticals in Cambridge, Massachusetts. The approval is based on the findings from the multicenter phase 2 clinical study CENTAUR published in The New England Journal of Medicine on September 3, 2020. 137 people with ALS participated in the six-month, randomized, placebo-controlled trial. After that, an open-label extension and long-term follow-up phase was done. Results indicated that the new ALS experimental treatment the FDA has approved might increase patients' lifespan by at least five to six months.

Before taking any medication, read about its side effects! The medication dosage your doctor prescribes depends on several factors, including the frequency and severity of your condition and other health issues. That's why it is always recommended to consult your doctor before taking any medication. Keep reading to learn more.


 

Are there any side effects associated with Relyvrio?

According to the results, the most commonly reported side effects were gastrointestinal issues such as diarrhea, nausea, salivary hypersecretion, and abdominal pain. 

However, looking at the tolerance level among people, the FDA has concluded the drug is safe for ALS treatment.


The advantage is that ALS patients can consume this new drug for ALS approved by the FDA along with other ALS drugs. This fact gives researchers hope that combining these drugs might provide a solution for people with ALS.

 

What is the cost of Relyvrio?

Keeping everything in mind, the drug producer Amylyx has said that the drug will cost around $12,504.24, or about $158,000 annually. 

For people with ALS insurance, Amylyx will provide them with lower copays.
 

References: 

https://www.ninds.nih.gov/news-events

https://www.everydayhealth.com/als/

https://www.npr.org/sections/health-shots

https://www.washingtonpost.com/health/

https://www.nbcnews.com/health/health-news/

https://alstreatment.com/

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Question and Answers

I am a 46yr old female, experienced hoarseness for more than a year after covid, I did a ct scan which reveals Avidly enhancing extra axial mass just posterior to the pineal gland. Pineal region meningioma vrs pineocytoma.

Female | 46

The CT scan showing a mass near your pineal gland could be a meningioma or a pineocytoma, two tumors that can have similar effects. Both of them may result in headaches and vision problems. A neurosurgeon can help run through the methods, and the main treatment can consist of surgery or other alternatives, as the specific type of tumor requires. 

Answered on 1st Oct '24

Dr. Gurneet Sawhney

Dr. Gurneet Sawhney

my grandmother went into a coma caused by hepatic encephalopathy. she was completely fine until her hands started trembling and she started vomiting one morning. there were no symptoms before that. she does have liver cirrhosis. she was taken to a hospital approximately 12 hours after this happened and placed into an ICU with a ventilator. she regained consciousness in about 24 hours, after the ammonia had been flushed out from the brain and the chest. she was in critical condition, but has been recovering well. now off the ventilator she does have noticeable personality changes yet good memory. this to me is extremely scary. she also seems less aware of the environment and takes longer to answer. could these affects be temporary or permanent?

Female | 70

Hepatic encephalopathy, which is the cause of her coma, can result in some temporary changes in personality and slow thinking. This is because the liver is not functioning properly and the toxins are building up in the brain. However, these effects might be lessened with treatment and time. 

Answered on 9th Sept '24

Dr. Gurneet Sawhney

Dr. Gurneet Sawhney

My name is shameer .I have surgery L1 burst .and loss control on bladder and bowel .11 months completed .how gain Bladder regaining power

Male | 23

It is tough to cope with the loss of control over the bladder and bowel. These problems may occur after L1 burst surgery due to injury to the nerves. Symptoms of this include not feeling the need to pee or poop or leaking. The positive news is that you can regain bladder control with pelvic floor exercises and bladder training. Request your doctor or physiotherapist to devise a plan for strengthening those muscles. 

Answered on 10th Sept '24

Dr. Gurneet Sawhney

Dr. Gurneet Sawhney

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