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Questions & Answers on "Bone Marrow Transplant" (271)
Dear Doctor, Due to my father's high blood viscosity, suspicion of polycythemia arises, necessitating blood draws every 3 weeks to maintain appropriate levels. At 69 years old, he experiences symptoms such as skin itching, swelling, head numbness, and fatigue. Currently, his JAK2 V617F mutation showed 0.8 then 1.2%, with JAK2 exon 12 negative and EPO at 13.4. Abdominal CT and chest X-ray are normal. After a few months of phlebotomy, his levels normalized. Now, we await the bone marrow biopsy results, which do not confirm Polycythemia Vera: "Microscopic description: The bone marrow biopsy sample shows somewhat hypocellular hematopoietic parenchyma relative to age, which is terminally mature. Myeloid ratio is 2:1 with dominance of late precursors; no blast cells are noted. The number of megakaryocytes is normal with no clustering. There is no interstitial fibrosis or lymphoid infiltrate. Diagnosis: Mature, hypocellular hematopoietic parenchyma without myeloproliferative features. Cytogenetic analysis confirmed male karyotype; no clonal chromosomal abnormalities detected. Indication for examination D7510 Secondary polycythemia Note Submicroscopic rearrangements, small structural chromosomal aberrations, DNA-level differences cannot be ruled out with the method used." I am quite confused as JAK2 positivity typically suggests PV, yet the biopsy suggests otherwise, possibly indicating secondary polycythemia. Could you please clarify based on this information what you personally think is more likely, Polycythemia Vera or another secondary cause? Thank you very much for your help.
Male | 67
Your father's symptoms and test results do suggest some complexity. The presence of JAK2 mutation often points towards Polycythemia Vera (PV), but the bone marrow biopsy does not show typical myeloproliferative features, suggesting it might be secondary polycythemia instead. Consult a hematologist, specializing in blood disorders, and can provide a more accurate diagnosis and appropriate treatment plan.
Answered on 3rd July '24
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I am very sick sir duwara duwara say bukhar aa raha hn and after that then urine mein blood bi aa raha hn and weekness bii What is my problem
Male | 44
Based on your explanation, you are familiar with fever and have also noticed blood in your urine. This could be a symptom of a urinary tract infection or a sign of kidney problems, both of which can also cause weakness. It would be best to consult a doctor within a few days to determine the cause and receive the appropriate care.
Answered on 23rd July '24
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Hi.. I'm always struggling with being very skinny and I can't gain weight and my iron level always drops, I did blood analysis and everything was good except iron level. I reached many doctors and they gave up because the diagnosis still dim ????. Thanks in advance doctor .
Female | 24
The typical symptoms of iron defusion consist of fatigue, weakness, and trouble gaining weight. The most prevalent cause of low iron is that you don't get enough of it in your diet. Iron-rich foods such as red meat, beans, and green leaves can do a good help. Besides consuming iron supplements, which should be prescribed by a doctor, one will also be able to improve one's iron levels. Don't forget to see your doctor to get more directions.
Answered on 9th Sept '24
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Hi good day I'm a male 36 years from Philippines I have a question regarding of my HIV symptoms My first encounter is last February 17 and I check a rapid test kit It was negative. But suddenly after 2 hours it show faded And after that I cannot sleep properly and there is a time on April 15 2024 I make a blood test in hospital 56 days after exposure Antigen and anti body test And thanks God it's negative And I buy again test kit 3 PCs For June July and Sept each month all test negative But this October I have rashes Red dot And hot sensation in my body in chest and back top and lower and my I feel my breath short And looking in Google That's why I feel uneasy again Please help me to elaborate my feeling Im afraid But I'm still believe everything will be alright and it must be negative
Male | 36
The symptoms you mention - rashes, red dots, hot sensation, and shortness of breath - may be caused by various reasons other than HIV. For instance, stress and anxiety are also potential causes of these symptoms. To be sure, you can ask a doctor.
Answered on 8th Oct '24
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৪৩ দিন পর হালকা রক্ত যাচ্ছে কিন্তু প্রেগন্যান্ট কিট পজিটিভ
Female | ২৩
In early pregnancy, light bleeding can sometimes happen and is known as implantation bleeding. It occurs when the fertilized egg attaches to the lining of the uterus. However, it's always important to rule out other potential causes like infections or hormonal changes. I recommend contacting your gynecologist to discuss your symptoms and possibly schedule an appointment for further evaluation. It's always better to be safe and get personalized medical advice in such situations.
Answered on 23rd Nov '25
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