The increased pain should be reported to your Doctor promptly as it may signal a severe reaction or complication. Your doctor will evaluate the case, possibly suggesting pain management methods, revising your treatment plan or recommend for a diagnostic. On the other hand, follow any post-injection care instructions given and do not self-medicate without seeking professional advice. Timely communicating with your Doctor ensures correct intervention at an appropriate time to mitigate the increased pain associated with stem cell injection and ensure that you recover safely post-therapy.