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  3. Dupixent for EOE: Effective Treatment Solutions
  • Gastroenterology

Dupixent for EOE: Effective Treatment Solutions

By Rahul Chauhan| Last Updated at: 22nd Mar '24| 16 Min Read

Eosinophilic esophagitis (EoE) is an inflammation of the esophagus, or stomach, caused by an abnormal amount of bacteria in the stomach. It is a common condition in children and adults and can lead to irritation, pain, and other symptoms.


Every 1 in 2000 people has EoE. However, the numbers are rising rapidly worldwide. It is so because EoE is a recently discovered condition. EoE can affect people of any age. Yet, studies have shown people in their 30s are the most prevalent.


Eosinophilic Esophagitis may not be life-threatening but is very concerning if left untreated. 


This shows why the approval of  for EoE is very significant! On 20th May 2022, the U.S. Food and Drug Administration approved Dupixent (dupilumab) to treat eosinophilic esophagitis (EoE). It is the first EoE treatment that the FDA has approved.

We have discussed the Dupixen for EoE treatment in detail. Continue reading to learn more! 


What is the Dupixent Treatment for Eosinophilic Esophagitis?
 

Dupixent is an artificial protein. This protein hinders the growth of the inflammatory pathways in the esophagus. It takes 16 weeks of regular Dupixent treatment to stabilize EoE. Dupixent is also preferred for treating pediatric patients at least 12 years of age. It can also be used for patients weighing over 40 kg.


Dupixent is the only therapy for eosinophilic esophagitis approved by the FDA. It is used for EoE treatment in adults. 

How is the Study Worked?

The FDA has approved this new medicine for EoE based on a randomized study in a parallel-group trial. This trial was conducted independently in separate groups of patients, including two 24-week treatment courses (Part A and Part B).

Between the two treatment courses (Part A and Part B), patients received either a placebo or 300 milligrams of Dupixent weekly.

Part A ExperimentPart B Experiment
In this study, 60% of the 42 patients who got Dupixent met the target level of esophageal eosinophil reduction. 
In contrast to 5% of the 39 patients who got a placebo.
In the Part B experiment, 59% of the 80 patients who received Dupixent achieved the predefined level of decreased eosinophils in the esophagus. Compared to 6% of the 79 patients who received a placebo,

“Today’s approval will fulfil an important unmet need for the increasing number of patients with eosinophilic esophagitis,” said Jessica Lee, MD, director of the Division of Gastroenterology in the FDA’s Center for Drug Evaluation and Research.


In 2017, Dupilumab was also approved to treat atopic dermatitis in adults and children aged up to 6, patients with moderate to severe asthma, or chronic rhinosinusitis with nasal polyposis.

Does Dupixent have any side effects?
 

Like every other drug, Dupixent also has adverse effects. Even though they are not severe, one must learn them before consuming them.


So pay attention! We have mentioned the adverse effects of Dupixent for EoE below; read them carefully!

There are several other factors that one should consider before taking Dupixent. 

We have compiled them below for you! 

So make sure you read them attentively!

What Should Patients Know Before Treatment?

  • Dupixent may cause severe allergic reactions in patients. If so, immediate medical attention is needed. Dupixent should be discontinued in such cases.
  • Patients with acute asthma should not take Dupixent for treatment. If taken, consult your doctor as soon as possible.
  • Immediately discontinuing Corticosteroids upon starting Dupixent for Eosinophilic Esophagitis treatment is not advised.
  • Patients should take the needed vaccinations before starting Dupixent treatment. It is not suggested to take any vaccination during Dupixent treatment.

References:

https://www.fda.gov/

https://www.sanofi.com/en/media-room/press-releases/2022/2022-07-14-05-00-00-2479427

https://www.ajmc.com/

https://www.uptodate.com/contents/whats-new-in-gastroenterology-and-hepatology

https://clinicaltrials.gov

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Question and Answers

Sir I passed out B.tech mechanical from Nit raipur 2023 from sc quota. I got placed at Vedanta Balco as a mechanical field operator and worked there for 1 year. Due to over work pressure, exploitation by the senior manager, My health deteriorated and mental issues got worse I was not getting any growth in my career. So I decided to resign and prepare for the Gate exam. My college roommate prakhar cleared Gate exam got Air 71 placed in iit bombay & then placed in Indian oil got 22 lakh package and some friends placed in IIT M.tech. I am really frustrated right now. I failed in gate 2025. For the past 1 year I have been diagnosed with major depression and schizophrenia. My life turned into hell Getting treatment from pramod gupta psychiatrist in durg he suggested to me to take olanzapine 5 mg for negative symptoms. I got mood swings which is the worst for me. I am feeling suicidal now Help me please... Also Suffering from stomach ulcer and GERD past 5 year taking pantaprazole 20 mg for burning sensation in stomach and vomiting. Its killing me Everyday. Currently working as sbi clerk getting cross selling pressure from management insurance mutual fund yono digital products like PMJJBY and PMSBY loan recovery field work pressure. help me.

Male | 24

The stress from work and the pressure to perform can really take a toll on our mental health. It's no wonder you're feeling overwhelmed. Depression and schizophrenia are serious conditions that can be influenced by a variety of factors, including stress, genetic predisposition, and life events. Seeking help from a psychiatrist  was a good first step. The medication he prescribed, olanzapine, is commonly used to manage symptoms of schizophrenia. However, it can sometimes cause mood swings as a side effect. It's crucial to communicate openly with psychiatrist about these side effects so he can adjust your treatment plan accordingly. Dealing with stomach issues like ulcers and GERD on top of everything else must be incredibly challenging. Pantoprazole is a standard treatment for these conditions, but it's essential to follow up with your gastroenterologist regularly to ensure it's effectively managing your symptoms. In terms of your current job situation at SBI, it sounds like the demands are adding to your stress levels. It might be helpful to have an open conversation with your manager about how you're feeling. Exploring stress management techniques, like mindfulness or exercise, could also be beneficial.

Answered on 10th Oct '25

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