Surgery is often recommended as a first-line treatment for brain tumors, but may not be the best option for everyone, especially for older adults who may have a higher risk of complications. Consult with a neurologist to discuss the best treatment options for your grandmother's specific case.

It can be gastrointestinal issue since you're experiencing chest pain, stomach pain, and a loss of appetite. Even stress and anxiety causes chest pain. Seek medical attention as soon as possible to properly diagnose and treat your symptoms. Check with a gastroentrologist first.

Based on the information you have provided, the pills you took on the 13th and 15th of last month may have affected your menstrual cycle. Contraceptive pills contain high levels of hormones that can disrupt your menstrual cycle and cause irregular bleeding. If you are concerned about a possible pregnancy, you can take a home pregnancy test to confirm. But wait at least a week after a missed period to take the test for accurate results or visit a gynecologist.

Scrotum pain can be due to serious testicular torsion or epididymitis, and requires prompt attention. Other causes can be hydrocele and inguinal hernia. Consult with a good urologist.

If the leg pain is so severe that affects walking then get it checked by an orthopedist as it could indicate a serious medical condition. Possible causes can be muscle strain, deep vein thrombosis, or nerve problems.

The painful swelling or bone-like feeling above the pelvis could be an abscess, hernia, cyst, or a tumor. Kindly get it checked with a gynecologist.
Given that she has a history of loose motions, stomach ache, and vomiting, its possible that the swelling is related to a previous gastrointestinal infection or inflammation.
Moreover her diabetes and current high blood sugar levels may also be contributing to her symptoms and complicating her condition. 

Sounds like you are experiencing symptoms of sleep disorder and depression. Speak to a neurologist regarding your sleep problems, and practice healthy sleeping habit.

You may experience some pain after the TKR especially during the first few months of recovery. I cannot tell as to how many days it will take to fully recover from pain. Consult an orthopedist.

If your ECG is normal then the pain may be due to muscle strain, anxiety or acid reflux. If medicines are not giving permanent relief, then talk to a doctor again, they may suggest few tests to find the exact reason of pain.

It generally suggest to avoid traveling for at least one to two weeks after a miscarriage, especially if you had a surgical procedure or experienced complications. 

Weight loss is influenced by genetics, hormones, and lifestyle habits. In your case, chronic constipation could be contributing to your difficulty in losing weight. Consult with a bariatic surgeon or gastroenterologist, to address your constipation and for weight loss.

Nipple discharge is caused by hormonal imbalances or medication side effects. While its not necessarily an indicator of pregnancy. And if you are taking contraceptive pills regularly and as directed, it's less likely that you are pregnant. Check with a gynecologist to confirm.