Stem Cell Transplant For Sickle Cell Disease( A Hope For Sickle Cell Patients)

Sickle Cell Disease is a genetic disorder that affects 20 million people worldwide. Back in the 1970s, 75% of babies that were born with this condition didn’t live to see their fifth birthday. With improving medical technology, a few treatments are available that can make this condition somewhat manageable. However, only one treatment has shown the potential to reverse this condition—stem cell treatment. Today, we have brought you all the information you will need to decide if this is the right treatment for you. Read on to know more.

  • Stem Cell

By Shalini Jadhvani

Updated on 15th, Apr'23

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Overview—Sickle Cell Disease

Sickle Cell Disease or Sickle Cell Anemia is a group of inherited disorders, where the shape of the red blood cells changes. As a result, hemoglobin levels are very low and blood flow is sometimes obstructed.


SCD Causes


It is a genetic disorder, where the child is affected if both parents have the mutated gene. 


Commonly observed symptoms are:


Symptoms of sickle cell

  • Anemia
  • Episodes of extreme pain
  • Swelling of hands and feet
  • Frequent infection
  • Delayed puberty
  • Vision problems

Sickle Cell Disease is diagnosed with a blood test and confirmed with genetic tests. So far, there is no cure for sickle cell disease.


However, there is one treatment that has reversed the condition in some patients—stem cell treatment, also known as hematopoietic bone marrow transplant


While this is a relatively new treatment, it is approved by the FDA, and has shown some exciting results in patients with severe symptoms.



Yes, you read that right! 


Can Stem Cell Transplant Cure Sickle Cell Disease? Does Stem Cell Transplant for Sickle Cell Disease Work?

The short answer is yes, it does. By using donor stem cells, this condition has been reversed and patients have gone on to live healthy lives.


We’re sure you’re now wondering just how does it work. 


To answer this question, let us first understand what a stem cell is. 

Stem cell

A stem cell is an immature cell found in our bodies, which can differentiate into any tissue. These stem cells are usually found in the bone marrow.


The stem cells induce the formation of new red blood cells in patients affected with sickle cell disease, which eventually replace all the damaged cells. 


Sounds intriguing, right?

Types of Stem Cell Transplants Used to Treat Sickle Cell Disease

Stem cells are available in several parts of our bodies. The ones that are most effective in treating sickle cell disease are hematopoietic stem cells, which are found in the bone marrow.


Allogeneic stem cell transplant for sickle cell disease is preferred. The donor should have the same blood and tissue type as the patient to qualify for this procedure.


In some cases, the patient’s own cells have also been used for this procedure, but the results have not been encouraging.


Benefits and Risks of Stem Cell Transplant for Sickle Cell Anemia

Benefits & Risks

Like every medical procedure, this one also has its own benefits and risks.

  • Can reverse the condition
  • Treats the root cause by replacing the damaged cells
  • Stem cells also induce the formation of healthy new cells, leading to better long-term results
  • Relatively non-invasive procedure
  • Graft-versus-host disease as donor cells are used
  • Chances that the treatment might not work

Doesn't the benefits outweigh the risks? 



How does one check if they are a good candidate for stem cell transplant for sickle cell? 


As several factors need to be considered first, your physician is the best person to answer this question. 


However, we have made a general list of requirements to get you started:


Eligibility criteria for stem cell transplant for sickle cell disease

  • Confirmed diagnosis with genetic testing
  • Should have some severe symptoms
  • Should have optimally functioning organs
  • Should not have undergone stem cell transplant in the past thirty days
  • Should not have a history of organ transplants or any other major medical issues

Stem cell transplant for sickle cell is mostly done for children younger than sixteen years of age who have severe complications from the disease. 


For adults, it is not recommended as the chances of risks from the treatment increases with increasing age. But research on new methods is ongoing which can soon make stem cell transplants for adults a successful reality. 


Types of Sickle Cell Disease Treated with Stem Cell Transplant

Types of sickle cell disease treated with stem cell transplant

There are several types of sickle cell disease, and nearly all of them have been successfully treated with stem cell transplants. 


How, you ask? 


We have laid it all out for you in the table below.

Type of Sickle Cell DiseaseHow Stem Cells Help
Hemoglobin SS Disease
  • This is the most common type of stem cell disease and exhibits the most severe symptoms.
  • Stem cells replace the damaged red blood cells, improving their oxygen-carrying capacity, and reducing anemia.
Hemoglobin SC Disease
  • This is the second most common type of sickle cell disease and has slightly less severe symptoms.
  • Stem cells are injected directly into the bone marrow, where they replace the damaged red cells.
  • Stem cells also release growth factors, prompting the formation of healthy red blood cells.
Hemoglobin SB+ (beta) Thalassemia
  • In this type of sickle cell disease, the size of the red blood cell is reduced.
  • While symptoms are not severe, anemia is still present. 
  • Stem cells can repair the red blood cells so that they return to their healthy size.


Procedure for Stem Cell Transplant for Sickle Cell Disease

If you are planning for a stem cell transplant, you might be interested in learning about the procedure, isn’t it? 

Procedure for stem cell transplant for sickle cell disease


While stem cell transplant in sickle cell disease might sound daunting, it is actually quite a simple procedure.

Step 1: Conditioning
  • The first step involves preparing your bone marrow to receive healthy stem cells.
  • High-dose chemotherapy is done to eliminate all the defective red blood cells.
  • This can last for a week to ten days.
Step 2: Extraction of stem cells
  • The donor is given growth factors one or two days before this procedure to increase the number of stem cells in their bone marrow.
  • Bone marrow tissue is extracted from the hip bone.
  • This procedure is done under local anesthesia, ensuring a pain-free experience, and only lasts an hour or two.
Step 3: Preparing the stem cells
  • Stem cells are separated from your bone marrow or adipose tissue by using a technique called ‘Density Gradient Technique.’
  • This part is done in a stem cell laboratory and takes about four hours.
  • The end product is a concentrated solution of stem cells.
Step 4: Stem cell transplantation
  • The stem cells are directly injected into your bone marrow.
  • This step is done about one week after the completion of chemotherapy.
  • It only takes a couple of hours, and local anesthesia is given to keep you completely comfortable.


As you can see, the entire procedure only lasts about eight to nine hours. 


However, it is spread out over two or three days for better patient comfort. You might also need to stay at the hospital for a week after the procedure.


What to Expect After Stem Cell Transplant for Sickle Cell Disease

Are you worried about what will happen after the procedure is completed?


You will be happy to know that you can resume your daily activities a week or ten days after your procedure.


Immediately after the procedure, you might feel a headache or some nausea. However, this is transient and resolves itself in a few hours. No long-term side effects have ever been reported in any clinical study, making this a completely safe procedure.




We should note here that you might still be feeling the side effects of chemotherapy at this point. You will also be asked to take immunosuppressants for a while, which can have side effects like nausea and vomiting.


So, while stem cell therapy itself barely has any side effects, the after-effects of chemotherapy might definitely make you feel miserable for a few weeks. In severe cases, your specialist will prescribe you something for symptomatic relief.




Stem cell treatment begins showing positive results about three to four weeks after the transplant. The stem cells continue to form new red blood cells for up to a year after the initial procedure.


During this time, you will see a steady improvement in your symptoms and lab results.


You can expect:

Improvements after stem cell transplant for sickle cell disease

  • A reduction in the severity of anemia and pain
  • Better hemoglobin levels in your blood tests
  • Improved shape of red blood cells on your blood smear

Unfortunately, these results are not permanent yet. You might need to repeat your transplant a few years down the line. However, this is only done if you display severe symptoms.


Success Rates of Stem Cell Transplant for Sickle Cell Disease 

Are you curious to know the success rate of the treatment?

Success rate of stem cell transplant for sickle cell disease


So far, there is no cure for sickle cell disease. The success rate of this condition is measured by a life expectancy of four years after the procedure.


In children, the success rate of this procedure is an astonishing 91%! In adults, this rate drops slightly to 85%.


What if Stem Cell Transplant for Sickle Cell Disease Doesn’t Work?

In about 15% of cases, stem cell transplant doesn’t work and the bone marrow continues to produce defective red blood cells.


Worried what if you fall in this 15%? 

In such situations, the stem cell cycle can be repeated. However, this can only be done after a thorough analysis by your hematologist. You are required to be fit enough to undergo another round of chemotherapy before the new transplant.


Around 22% of patients also show a relapse. In aggressive cases, the relapse occurs within six months of the transplant. In a few cases, the relapse is seen one or two years after the procedure.


Since stem cell transplant is currently the only treatment that can reverse sickle cell disease, at this point it is wise to repeat a cycle.


Cost of Stem Cell Transplant for Sickle Cell Disease

Cost of stem cell transplant for sickle cell disease

How does a stem cell transplant affect my bank account? 

This is one of the most critical questions for any medical treatment.


Stem cell transplant for sickle cell cost depends on several factors including the severity of your condition, your specialist fees, and the facility you choose for your treatment.


In India, this treatment will set you back by 7000 to 30,000 USD. This cost includes your hospital stay and all diagnostic tests. In comparison, the same treatment costs upward of 50,000 USD in the US!


The good news is, since this procedure is approved by the FDA, a few medical insurances have started covering a part of or the entire cost. However, the number of insurance companies offering this service is currently still limited.


A Research Explaining Present and Future Scope and Challenges of Stem Cell Transplant for Sickle Cell Anemia

Sickle cell stem cell transplant has come a long way in the past thirty years. The long-term survival rate has increased from 25% to 90%. 


Stem cell treatment is also the only treatment that can reverse this condition. However, a few challenges still exist.


Researchers still need to work on reducing relapse rates. There is also some discrepancy in the delivery method of the stem cells and the type of stem cells used, which needs to be addressed.


Nonetheless, stem cell treatment has the potential to one day cure sickle cell disease, and we will certainly be watching these developments with interest.


Do you think stem cell therapy is the right treatment for your condition?


Call today and get free Consultation!



Frequently Asked Questions

Why is embryonic stem cell considered most useful?

Does stem cell therapy work?

What to expect after stem cell therapy? For speedier recovery, are there any post-treatment guidelines that need to be followed?

How to prepare for stem cell therapy?

Is stem cell therapy legal in India?

Is Bone Marrow Transplant a cure for Leukaemia?

What is the use of a bone marrow transplant?

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Question and Answers

Any estimate after how many days stem cell therapy can come

Male | 21

Stem cell therapy is a complex and evolving, and the outcomes can differ from person to person. I cannot comment as to when and how many days it will take for it to start full fleged.

Answered on 22th May'23

Dr. Pradeep Mahajan

Dr. Pradeep Mahajan

I have end-stage osteoarthritis of both ankles, making it painful to walk. I am interested in getting stem cell therapy. If it has proven successful in osteoarthritis of the ankles success to be would been reduced pain and increased mobility. Two years ago I hiked often and I miss my active lifestyle

Female | 83

Stem cell therapy for osteoarthritis is a promising treatment option, but it's important to understand that it is still considered an experimental treatment and its long-term effects are not fully known. It may help reduce pain and improve your quality of life. So consult the best hospitals and doctors for a good stem cell treatment.

Answered on 5th May'23

Dr. Pradeep Mahajan

Dr. Pradeep Mahajan

What is stem cell penile enlargement cost?

Male | 28

In ayurveda, there is NO medicines (tablets, capsules, goli, bati, oil, tail, cream, powder, churan, vaccum pumps, tension rings, rings, exercise, yoga. or any other type of medicines or procedures) available that could Increase the size of the penis (i.e. length & girth.. motai of penis).

Even if one is ready to spend lacs of Rupees.

Size of penis is not important for satisfactory sexual relationships.

For this one should have a good hardness in the penis & should take sufficient time before discharge.

So please forget about increase in size of penis.

If you have any problem in getting hardness in the penis or you are suffering from quick discharge, then you may contact Your Family Doctor or chat with me on my private chat.

Or you can contact me in my clinic

We can send you the medicines by courier also

My website is


Answered on 27th July'22

Dr. Arun Kumar

Dr. Arun Kumar

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