What is Intracytoplasmic morphologically selected sperm injection? (IMSI)

Get complete knowledge about IMSI (Intracytoplasmic morphologically selected sperm injection) Difference between IMSI & ICSI, success rate & when IMSI is recommended

By Pankaj Kamble

Updated on 04th, Jan'22

There are many advanced techniques in the field of IVF which have greatly contributed in its popularity.One such technique is IMSI (Intracytoplasmic morphologically selected sperm injection).


This is a new sophisticated method of sperm selection where the sperm is selected using a high power magnification microscope.This microscope provides much greater magnifying power i.e around 6000 times which is way better then ICSI technique that gives around 400 times.


Therefore, this technique allows scientists/biologists to assess the structure of sperm that is having highest chance of achieving a successful fertilization and exclude the sperm with suspected abnormalities .


IMSI treatment is variation of ICSI which is useful in sperm selection for the process of fertilization. Here, the sperm selection is done on prior basis i.e before microinjection takes place.


So, what is the exact difference between ICSI and IMSI??


Now, let’s clear your doubt regarding this..

difference between ICSI and IMSI


What is the procedure of IMSI?

The procedure of IMSI is very similar to ICSI.

To stimulate production of eggs in ovaries fertility drugs are to given female partner.

1. SELECTION: Initially, selection of sperm is done under a microscope having magnifying power 15 times more effective than ICSI.

2. DISCARD: The internal morphology of sperm can be easily examined with the help of sophisticated microscope and those sperms with abnormilites can be easily discarded.

3. INJECTION: Through ICSI (Intracytoplasmic sperm injection) the sperm which is selected is injected into the egg. If successful then the eggs will be fertilized and embryos will be formed.

4. TRANSFER: With the help of a thin catheter one or three embryos are selected and inserted deep inside the uterus by the gynaecologist.


The following videos will help you understand IMSI procedure more clearly:


Now you surely must be wondering


When is IMSI recommended??

When is IMSI recommended?


What are the Success Rate and Side Effects OF IMSI?

Success rate of IMSI is believed to be higher than ICSI technique. However, depending on each individual case the success rate varies greatly.


There is 38% chance of achieving live birth with ICSI method but in case of IMSI the probability of achieving live birth would be between 30%-63%.


Generally, the risk associated with IMSI regarding miscarriage would be approximately 13%to 25%.


However, you should be aware about the fact that a woman’s age play a very important role when it comes to fertility technique. Depending on the age, some of the eggs may be abnormal and therefore at the time of fertilization it may result in abnormal embryo.

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