25 years of experience
Answered on 17th Jan '24
Acute gout is a contraindication to the use of allopurinol as its initial usage could possibly increase symptoms. It may therefore increase serum uric acid levels temporarily when allopurinol is initiated against an acute attack of gout given the mobilization of urate crystals. This may result in aggravation of inflammation and the patient’s condition gets worse. Allopurinol is usually initiated following the acute phase to prevent further gout attacks by reducing total uric acid levels in the body. Managing acute gout flares may involve the use of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine or corticosteroids.
21 years of experience
Answered on 11th Jan '24
Acute gout is a contraindication to the use of allopurinol as its initial usage could possibly increase symptoms. It may therefore increase serum uric acid levels temporarily when allopurinol is initiated against an acute attack of gout given the mobilization of urate crystals. This may result in aggravation of inflammation and the patient’s condition gets worse. Allopurinol is usually initiated following the acute phase to prevent further gout attacks by reducing total uric acid levels in the body. Managing acute gout flares may involve the use of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine or corticosteroids.
13 years of experience
Answered on 7th June '22
Allopurinol cause urate lowering resulting in urate crystals being shed from articular cartilage into the joint space, resulting in acute inflammation ,hence it should not be used.