Company logo
Get Listed

Get answers for your health queries from top Doctors for FREE!

100% Privacy Protection

100% Privacy Protection

We maintain your privacy and data confidentiality.

Verified Doctors

Verified Doctors

All Doctors go through a stringent verification process.

Quick Response

Quick Response

All Doctors go through a stringent verification process.

Reduce Clinic Visits

Reduce Clinic Visits

Save your time and money from the hassle of visits.

  1. Home /
  2. Blogs /
  3. Newest Treatment For Multiple Myeloma 2022 - FDA Approved

Newest Treatment For Multiple Myeloma 2022 - FDA Approved

There is still no cure for multiple myeloma. But the newest treatment for multiple myeloma shows promising hopes. Read all about Carvykti here.

  • Cancer
By Aranya Doloi 15th Oct '22 2nd Feb '24
Blog Banner Image

Multiple myeloma is a form of rare blood cancer. It happens in the plasma cells. They are a type of white blood cell. They make antibodies called immunoglobulins. Immunoglobulins fight infection. Multiple myeloma occurs when plasma cells become cancerous and multiply uncontrollably. The cells produce abnormal antibodies called M proteins. As of September 2020, 160,000 multiple myeloma cases were worldwide, with 106,000 deaths. 

According to the American Cancer Society's projections for 2022, an estimated 34,470 new cases will be reported (19,100 in men and 15,370 in women) only in the US. And 12,640 fatalities are anticipated (7,090 in men and 5,550 in women).


While multiple myeloma is incurable, treatments have grown a great deal. A plethora of innovations for new myeloma treatments have been available since 2015. New drugs for multiple myeloma treatment helped people live longer and enjoy a better quality of life.


Ciltacabtagene autoleucel, sold under the brand name Carvykti, is the latest FDA-approved drug in oncology. It is a kind of Car-T therapy for adult patients with refractory or relapsed multiple myeloma.

Stay with us till the end to learn more about this newest treatment for multiple myeloma.

More About: Ciltacabtagene Autoleucel (Carvykti)


The Food and Drug Administration approved another Car-T therapy for multiple myeloma on February 28, 2022. Ciltacabtagene autoleucel (Carvykti) is the new drug for multiple myeloma. It is the newest treatment for multiple myeloma patients who are not responding to treatment or whose cancer has returned. This treatment is also for patients undergoing four or more cancer cure therapies. 


Doctors tailor each dose of ciltacabtagene autoleucel treatment using patients' own T cells. T cells are disease-fighting white blood cells that attack myeloma. Doctors genetically change patients' T cells and put them back in the body. 


FDA gave its approval based on the trial Cartitude-1. Almost every patient in the trial saw a reduction in the amount of cancer. Moreover, many participants also had their cancer checked for more than a year. 

Dr. Davies said CAR T-cell therapy “works in a completely different way than our standard treatments and, therefore, it offers a different way of killing [drug] resistant myeloma cells, which really is the key.”


More details about trial Cartitude-1


Cartitude-1 was a small, multicenter clinical trial comprising 97 patients. All of them had already received many lines of therapy for multiple myeloma. These included a proteasome inhibitor (PI), an anti-CD38 monoclonal antibody, and an immunomodulatory agent (IMiD). 

Observation:

  • Researchers gave all patients a single infusion of cilta-cel. 
  • 98% of the patients responded to the treatment. 95 out of 97 patients saw a reduction of cancer in their bodies. 
  • 78% of the patients showed stringent complete responses. This means they showed no signs of cancer in blood or bone marrow on sophisticated tests. 


Ciltacabtagene autoleucel treatment is incredibly good news about multiple myeloma. All other FDA-approved drugs for multiple myeloma have a success rate of 30%. This is because multiple myeloma is a recurrent disease. Hence, it is essential to keep innovating new drugs and therapies to improve the patient's quality of life. Moreover, the latest treatment has also shown a 100% response rate in the clinical trial. This brings hope for the innovation of resistant treatment for myeloma. 


What are the side effects of Ciltacabtagene Autoleucel (Carvykti)?

During trial Cartitude-1, patients experienced infections, nerve tingling or pain, and cytokine release syndrome. Such side effects are typical of Car T-cell therapy. 


Moreover, the packaged label of Carvykti comes with warnings for six potentially life-threatening effects. They are,

  • hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS), 
  • Guillain-Barre syndrome, cytokine release syndrome, parkinsonism, prolonged periods of low blood counts, and 
  • immune effector cell–associated neurotoxicity syndrome (ICANS). 


In its efforts to evaluate the long-term safety of Carvykti, the FDA has asked manufacturer Janssen Pharmaceutical to conduct a post-marketing observational study. The study will focus on patients who are treated with ciltacabtagene autoleucel.

References:

https://pubmed.ncbi.nlm.nih.gov/32335971/

https://www.mskcc.org/news

https://www.fda.gov

https://www.targetedonc.com/

Related Blogs

Blog Banner Image

Dr. Sandeep Nayak - Best Oncologist in Bangalore

Dr. Sandeep Nayak - Best oncologist in Bangalore. Experience of 19 years. Consults at Fortis, MACS & Ramakrishna. To book an appointment, call @ +91-98678 76979

Blog Banner Image

Eye Cancer Treatment in India: Advanced Care Solutions

Explore advanced eye cancer treatment in India. Renowned specialists, state-of-the-art facilities ensure comprehensive care and better outcomes. Discover options today!

Blog Banner Image

PET Scan in Mumbai: Revealing Insights with Advanced Imaging

You’ll find all the available details for the PET scan in Mumbai on this page.

Blog Banner Image

Cancer Treatment in India: Costs, Hospitals, Doctors 2024

Discover cutting-edge cancer treatment in India. Renowned specialists, advanced technology ensure comprehensive care and better outcomes. Explore options today!

Blog Banner Image

Organ Specific Cancer Treatment in India

Organ-specific cancer treatment in India. Explore cutting-edge therapies, compassionate care, and renewed possibilities for healing. Learn more now!

Blog Banner Image

Best Medical Tourism Companies in India 2024 List

Discover excellence in healthcare with top-rated Medical Tourism Companies in India. Your journey to world-class treatment begins here.

Blog Banner Image

10 Best Hospitals in Istanbul - Updated 2023

Looking for the best hospital in Istanbul? Here is a compact list for you of the 10 Best Hospitals in Istanbul.

Blog Banner Image

15 Best Places of Hair Donation for Cancer Patients in India

Explore the best places for hair donation for cancer patients in India. Join the meaningful movement with our guide to Hair Donation for Cancer Patients in India, making a positive impact with every strand

Question and Answers

Hello. My Mother is in Bangladesh and has been diagnosed with breast cancer. She has a lump of 2x0.2x0.2 cm and Nuclear grade II. Could you please let me know - 1. what is the stage of her cancer? 2. What would be the treatment? 3. What would be the cost for treatment in India. Thanks and regards,

The staging will depend on the status of lymph nodes and other factors. Treatment will include surgery as major part along with chemo and radiation. You can visit a surgical oncologist in Mumbai for advice for the same.

Answered on 19th June '24

Dr. Akash Dhuru.

Dr. Akash Dhuru.

Hi, I have stage 2 Breast cancer. Which is the best hospital for treatment? Please suggest a name of doctor also.

Female | 34

You can visit your nearest Surgica Oncologist. If you are in Mumbai you can connect with me. Dr Akash Dhuru (Surgical Oncologist)

Answered on 19th June '24

Dr. Akash Dhuru.

Dr. Akash Dhuru.

Sir my mother has been affected by peri ampullary carcinoma. She is 45 years old now. I need help from you. In the world i don't have anyone except my mother.

Female | 45

This form of cancer causes symptoms such as jaundice, weight loss, and belly pain. It starts when cells near the ampulla of Vater begin growing out of control. Treatment typically involves surgery followed by chemotherapy. You must collaborate closely with her physician to determine the most effective course of action for your mother. Be strong and be there for her during this difficult time.

Answered on 10th June '24

Dr. Sridhar Susheela

Dr. Sridhar Susheela

Does cancer come back in everyone who is cured after treatment?

Male | 22

When an individual undergoes treatment and the disease fades away, it’s a relief. Nonetheless, there are times when it recurs after going into remission. It is contingent on the kind of malignancy one has as well as the method used for healing it. Signs that can indicate its reoccurrence may be similar to those experienced during the first onset such as unexplained weight loss, fatigue, or formation of new masses. To avoid its resurgence, you need to keep seeing your doctor for regular checkups besides living healthily. 

Answered on 11th June '24

Dr. Sridhar Susheela

Dr. Sridhar Susheela

He is infected of perenial fistula. And for years ,almost 9 surgeries was operated for him. And his colonscopy result before 1 and half year said normal. But now when MRI is taken ,shows some small tumors and may be T4N1MX adenocarcinoma cancer IS created but the other results like colonoscopy says normal , biopsy result says non diagnostic, CT SCAN result says it is better for him to take the test after 6 months, the blood test says normal and other organs like kidney, liver...are all normal. He has normal medical result apart from the cancer and now he is taking chemiotherapy treatment so what shall I do

Male | 64

When you have adenocarcinoma, you must stick to the treatment plan your doctor gives you. Chemotherapy is used often for treating this type of cancer. Just try to follow the treatment schedule, eat well, and get enough rest. 

Answered on 19th June '24

Dr. Ganesh Nagarajan

Dr. Ganesh Nagarajan

Cancer Hospitals In Other Cities

Top Related Speciality Doctors In Other Cities

Cost Of Related Treatments In Country