Newest Treatment For Multiple Myeloma 2022 - FDA Approved

There is still no cure for multiple myeloma. But the newest treatment for multiple myeloma shows promising hopes. Read all about Carvykti here.

  • Cancer

By Aranya Doloi

Updated on 28th, Apr'23

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Multiple myeloma is a form of rare blood cancer. It happens in the plasma cells. They are a type of white blood cell. They make antibodies called immunoglobulins. Immunoglobulins fight infection. Multiple myeloma occurs when plasma cells become cancerous and multiply uncontrollably. The cells produce abnormal antibodies called M proteins. As of September 2020, 160,000 multiple myeloma cases were worldwide, with 106,000 deaths. 

According to the American Cancer Society's projections for 2022, an estimated 34,470 new cases will be reported (19,100 in men and 15,370 in women) only in the US. And 12,640 fatalities are anticipated (7,090 in men and 5,550 in women).

While multiple myeloma is incurable, treatments have grown a great deal. A plethora of innovations for new myeloma treatments have been available since 2015. New drugs for multiple myeloma treatment helped people live longer and enjoy a better quality of life.

Ciltacabtagene autoleucel, sold under the brand name Carvykti, is the latest FDA-approved drug in oncology. It is a kind of Car-T therapy for adult patients with refractory or relapsed multiple myeloma.

Stay with us till the end to learn more about this newest treatment for multiple myeloma.

More About: Ciltacabtagene Autoleucel (Carvykti)

The Food and Drug Administration approved another Car-T therapy for multiple myeloma on February 28, 2022. Ciltacabtagene autoleucel (Carvykti) is the new drug for multiple myeloma. It is the newest treatment for multiple myeloma patients who are not responding to treatment or whose cancer has returned. This treatment is also for patients undergoing four or more cancer cure therapies. 

Doctors tailor each dose of ciltacabtagene autoleucel treatment using patients' own T cells. T cells are disease-fighting white blood cells that attack myeloma. Doctors genetically change patients' T cells and put them back in the body. 

FDA gave its approval based on the trial Cartitude-1. Almost every patient in the trial saw a reduction in the amount of cancer. Moreover, many participants also had their cancer checked for more than a year. 

Dr. Davies said CAR T-cell therapy “works in a completely different way than our standard treatments and, therefore, it offers a different way of killing [drug] resistant myeloma cells, which really is the key.”

More details about trial Cartitude-1

Cartitude-1 was a small, multicenter clinical trial comprising 97 patients. All of them had already received many lines of therapy for multiple myeloma. These included a proteasome inhibitor (PI), an anti-CD38 monoclonal antibody, and an immunomodulatory agent (IMiD). 


  • Researchers gave all patients a single infusion of cilta-cel. 
  • 98% of the patients responded to the treatment. 95 out of 97 patients saw a reduction of cancer in their bodies. 
  • 78% of the patients showed stringent complete responses. This means they showed no signs of cancer in blood or bone marrow on sophisticated tests. 

Ciltacabtagene autoleucel treatment is incredibly good news about multiple myeloma. All other FDA-approved drugs for multiple myeloma have a success rate of 30%. This is because multiple myeloma is a recurrent disease. Hence, it is essential to keep innovating new drugs and therapies to improve the patient's quality of life. Moreover, the latest treatment has also shown a 100% response rate in the clinical trial. This brings hope for the innovation of resistant treatment for myeloma. 

What are the side effects of Ciltacabtagene Autoleucel (Carvykti)?

During trial Cartitude-1, patients experienced infections, nerve tingling or pain, and cytokine release syndrome. Such side effects are typical of Car T-cell therapy. 

Moreover, the packaged label of Carvykti comes with warnings for six potentially life-threatening effects. They are,

  • hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS), 
  • Guillain-Barre syndrome, cytokine release syndrome, parkinsonism, prolonged periods of low blood counts, and 
  • immune effector cell–associated neurotoxicity syndrome (ICANS). 

In its efforts to evaluate the long-term safety of Carvykti, the FDA has asked manufacturer Janssen Pharmaceutical to conduct a post-marketing observational study. The study will focus on patients who are treated with ciltacabtagene autoleucel.


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Question and Answers

Answered on 26th May'23

Dr. Ganesh Nagarajan

Dr. Ganesh Nagarajan

Answered on 17th May'23

Dr. Ganesh Nagarajan

Dr. Ganesh Nagarajan

I am a patient of rectal cancer with adenocarcinoma with cignet ring cell carcinoma, and got immunotherapy in ayurvedic through oral medications also got almost cured for three months. But again rectal bleeding and severe pain started and there is wound pist radiotherapy just at bottom inside layer of anus.

Male | 33

It's possible that the wound from your radiotherapy treatment has not fully healed or that there may be other factors contributing to your symptoms. You should communicate openly with your doctor about your symptoms, concerns, and treatment history, as they will have the best understanding of your problems. 

Answered on 12th May'23

Dr. Donald Babu

Dr. Donald Babu

Can you cure colon cancer stage 4

Female | 37

Curing colon cancer at stage 4 is difficult but it is not impossible. The primary treatment for stage 4 colon cancer is chemotherapy, which aims to shrink the cancer or in some cases radiation therapy is used. Consult an oncologist who can recommend a proper treatment plan for you.

Answered on 2nd May'23

Dr. Ganesh Nagarajan

Dr. Ganesh Nagarajan

My maternal aunt is diagonised with cancer. She is in the first stage and Dr. From TATA said for operation. But her financial condition is not good. Is there any option for subsidies treatment to save her life.

Female | 56

There are many government schemes and programs in India that provide financial assistance for cancer treatment like the Pradhan Mantri Jan Arogya Yojana (PMJAY), also known as Ayushman Bharat. You can check if your aunt is eligible for this scheme, and if so, she can avail cashless treatment for cancer in any empaneled hospital. You can check thjere are various non-governmental organizations (NGOs) and cancer foundations for financial assistance.

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