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  3. Refractory Multiple Myeloma- New FDA Approved Treatment 2022

Refractory Multiple Myeloma- New FDA Approved Treatment 2022

Discover insights into refractory multiple myeloma. Explore treatment options, clinical trials, and expert care for managing this challenging condition.

  • Cancer
  • Blood Cancer Treatment
By Ipshita Ghoshal 7th Dec '22 26th Mar '24
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Multiple myeloma is one of the rarest cancers which grows in plasma cells in blood. In 2022, an estimated 34,470 cases of multiple myeloma were recorded in the United States. The death toll went up to 12,640 in the United States. Only 55% of people can survive up to 5 years after a cancer diagnosis. Most people struggle to live that long after being diagnosed with multiple myeloma.

According to the International Myeloma Foundation, relapses of multiple myeloma are common. The majority of patients experience remissions and relapses numerous times over the course of their illness.

The initial remission stage may last two to three years or longer for those with no additional risk factors.

According to a study in 2016, relapse rates in 511 patients with multiple myeloma after therapy from 2006 to 2014 were examined.

16 percent of the individuals had an early relapse within a year. But 84% either experienced a relapse within a year or had none at the time of the follow-up.

Researchers keep on studying the disease to develop various refractory multiple myeloma treatments to increase the relative survival rate of patients.

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More About: New Multiple myeloma relapse treatment

On 25th October 2022, the FDA approved a new treatment for relapsed refractory multiple Myeloma. Tecvayli (Teclistamab) got accelerated approval from the FDA. Tecvayli is approved for those who did not respond positively to four or more treatment cycles.

As per the FDA, this is the first BCMA-directed CD3 T-cell engager drug. This drug for myeloma relapse works by sticking to certain kinds of T cells that attack the cancer cells after finding them.

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The approval of Tecvayli (Teclistamab)

Teclistamab was evaluated in the study named MajesTEC-1. The study sample comprised 110 patients who had already received three prior therapies. The study's main objective was to determine the overall response rate and the percentage of patients who showed reduced symptoms of relapsed multiple myeloma. 

After the study, it was found that the overall response rate was 61.8%. In 90.6% of the patients, the positive response lasted more than six months. The positive response lasted for more than nine months in patients with excellent ORR. 

Hence Tecvayli was granted accelerated approval.


 

What are the adverse effects of Tecvayli?

There are a few side effects linked to Tecvayli, as observed among 20% of the patients who were administered Tecvayli during the Clinical study:


 

Safety information concerning Tecvayli

  • Tecvayli has a Boxed Warning for cytokine release syndrome, a disease in which the body releases an excessive amount of the inflammatory proteins known as cytokines.
  • Hepatotoxicity, infections, neutropenia, hypersensitivity, and embryo-fetal toxicity are among the warnings and precautions related to Tecvayli. 

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References:

https://pubmed.ncbi.nlm.nih.gov/35560063/

https://www.myeloma.org/treatments-subsequent-relapse

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541860/

https://www.webmd.com/cancer/multiple-myeloma/refractory-multiple-myeloma


 

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Question and Answers

Hello. My Mother is in Bangladesh and has been diagnosed with breast cancer. She has a lump of 2x0.2x0.2 cm and Nuclear grade II. Could you please let me know - 1. what is the stage of her cancer? 2. What would be the treatment? 3. What would be the cost for treatment in India. Thanks and regards,

The staging will depend on the status of lymph nodes and other factors. Treatment will include surgery as major part along with chemo and radiation. You can visit a surgical oncologist in Mumbai for advice for the same.

Answered on 19th June '24

Dr. Akash Dhuru.

Dr. Akash Dhuru.

Hi, I have stage 2 Breast cancer. Which is the best hospital for treatment? Please suggest a name of doctor also.

Female | 34

You can visit your nearest Surgica Oncologist. If you are in Mumbai you can connect with me. Dr Akash Dhuru (Surgical Oncologist)

Answered on 19th June '24

Dr. Akash Dhuru.

Dr. Akash Dhuru.

Sir my mother has been affected by peri ampullary carcinoma. She is 45 years old now. I need help from you. In the world i don't have anyone except my mother.

Female | 45

This form of cancer causes symptoms such as jaundice, weight loss, and belly pain. It starts when cells near the ampulla of Vater begin growing out of control. Treatment typically involves surgery followed by chemotherapy. You must collaborate closely with her physician to determine the most effective course of action for your mother. Be strong and be there for her during this difficult time.

Answered on 25th June '24

Dr. Sridhar Susheela

Dr. Sridhar Susheela

Does cancer come back in everyone who is cured after treatment?

Male | 22

When an individual undergoes treatment and the disease fades away, it’s a relief. Nonetheless, there are times when it recurs after going into remission. It is contingent on the kind of malignancy one has as well as the method used for healing it. Signs that can indicate its reoccurrence may be similar to those experienced during the first onset such as unexplained weight loss, fatigue, or formation of new masses. To avoid its resurgence, you need to keep seeing your doctor for regular checkups besides living healthily. 

Answered on 11th June '24

Dr. Sridhar Susheela

Dr. Sridhar Susheela

He is infected of perenial fistula. And for years ,almost 9 surgeries was operated for him. And his colonscopy result before 1 and half year said normal. But now when MRI is taken ,shows some small tumors and may be T4N1MX adenocarcinoma cancer IS created but the other results like colonoscopy says normal , biopsy result says non diagnostic, CT SCAN result says it is better for him to take the test after 6 months, the blood test says normal and other organs like kidney, liver...are all normal. He has normal medical result apart from the cancer and now he is taking chemiotherapy treatment so what shall I do

Male | 64

When you have adenocarcinoma, you must stick to the treatment plan your doctor gives you. Chemotherapy is used often for treating this type of cancer. Just try to follow the treatment schedule, eat well, and get enough rest. 

Answered on 19th June '24

Dr. Ganesh Nagarajan

Dr. Ganesh Nagarajan

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